The Royal Veterinary College, UK
Tel: +44 (0)1707 666333
TB, molecular microbiology, target identification and validation, genetic manipulation
I completed a BSc in Genetics at the University of Swansea and a PhD in antibiotic resistance in E. coli at the University of Bristol. I began to start work as a Post-Doctoral Fellow with Mycobacterium tuberculosis in 2000 first at the London School of Hygiene and Tropical Medicine and subsequently at The Royal Veterinary College.
My work with TetR transcriptional regulators in M. tuberculosis has led to a greater understanding of the carbon sources used by this intracellular bacterium during infection. I continue to work of this family of regulators and have shown that they regulate a diverse range of functions, some of which are required for intracellular survival. I am currently trying to utilise transposon based methods to determine the bacterial genetic requirements for survival during mycobacterial infection and hope that this information will lead to the identification of new therapeutic targets/vaccines for both human and bovine tuberculosis. I have a long history of genetic manipulation of TB and I am keen to try and develop new technologies such as CRISPRi.
Profile page on ResearchGate
Available at Royal Veterinary College