Simone Joosten
Immunologist Leiden University Medical Center Email: sajoosten@lumc.nl
VALIDATE Role: Network Investigator
Research Keywords: TB, vaccine, biomarkers, functional assays, DURTs
Biography: Having a biomedical background with a specialization in immunology, my main interest is to understand the human immune system in health and disease. Over the last decade, my group has been working on host immunity towards tuberculosis (TB). TB biomarkers are one of the key subjects we have been working on, including bioprofiling of clinical samples. In addition, we have been interested in cellular immunity towards Mycobacterium tuberculosis (Mtb). My group aims to unravel the pathophysiological role of cellular immune responses in the combat against Mtb. We focus in particular on HLA-E restricted CD8+T-cells, B-cells and more recently also monocyte subsets. We aim to combine clinical data and samples with a functional immunological characterization of the responses.
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