Sineenart Sengyee
Postdoctoral Researcher Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, USA
VALIDATE Role: Network Associate
Research Keywords: Melioidosis Biography: My current research is working to identify the host immune responses in melioidosis patients which can provide valuable insights into the disease’s pathogenesis, mortality prediction and validation of genetic factors influencing survival in melioidosis. Additionally, I am working on identifying the immune responses against melioidosis subunit vaccine candidates in animal models to develop safe and effective vaccine candidates for combating melioidosis.
Related Websites:
Key Publications: Sengyee S, Yarasai A, Janon R, Morakot C, Ottiwet O, Schmidt LK, West TE, Burtnick MN, Chantratita N, Brett PJ. Melioidosis Patient Survival Correlates with Strong IFN-γ Secreting T Cell Responses Against Hcp1 and TssM. Front Immunol. 2021. Jul 30;12:698303. Sengyee S, Yoon SH, West TE, Ernst RK, Chantratita N. Lipopolysaccharides from Different Burkholderia Species with Different Lipid A Structures Induce Toll-Like Receptor 4 Activation and React with Melioidosis Patient Sera. Infect Immun. 2019. Nov 18;87(12):e00692-19. Sengyee S, Saiprom N, Paksanont S, Limmathurotsakul D, Wuthiekanun V, Chantratita N. Susceptibility of Clinical Isolates of Burkholderia pseudomallei to a Lipid A Biosynthesis Inhibitor. Am J Trop Med Hyg. 2017;97(1):62-7. Sengyee S, Yoon SH, Paksanont S, Yimthin T, Wuthiekanun V, Limmathurotsakul D, et al. Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation. PLOS Negl. Trop. Dis. 2018;12(2). |
