Somasish Ghosh Dastidar

somasish profile pic

Professor and Ramalingaswami Fellow,

Kasturba Medical College, Manipal, India.

Tel: +91-8088872591 





Network Associate


Research Keywords: 

Cell and Molecular Biology, Neurobiology, Animal models, Preclinical trials, Animal behaviour tests, CRISPR/Cas9 library screening, mammalian cells, primary cells, cell signalling. 


Dr. Somasish Ghosh Dastidar graduated from the University of Pune with Honours in Microbiology and with Masters in Biotechnology from Visva Bharati University. His Master’s thesis work comprised the role of Role of Aeromonas hydrophila in the aetiology of AES. Somasish did his PhD from the University of Texas at Dallas in Cell and Molecular Biology in the field of Neurodegeneration and Neurodevelopmental disorder such as Rett Syndrome with Prof. Santosh D’mello. His postdoctoral training was with Dr. Al LaSpada, a world leader in Neurogenetics and Neurotherapeutics, at University of California San Diego and later at Duke University. Dastidar’ s postdoctoral training continued in neurodegeneration and aging, where he learned the relevance of noncoding RNA, autophagy, proteasomal degradation and chaperone machinery during aging and age related disorders such as Parkinson’s and ALS. Somasish has extensive expertise in making and characterizing transgenic mice, working with knock in mice and triple transgenic mice. He uses mammalian cell lines, primary neuronal cells, primary glial cells and induced Pluripotent Stem cells as models to test his scientific hypothesis with a clear and defined focus on identifying genetic targets for therapeutic exploitations/possibilities. He is currently establishing CRISPR/Cas9 based functional genomic screening and micro array analysis to identify genetic targets and pathways altered in Parkinson’s and astrocytomas as direct goals of his Ramalingaswami Fellowship project. Somasish has published in high impact factor papers such as Cell Metabolism, Acta Neuropathologica, Nature Neuroscience, Journal of Neuroscience, Journal of Biological Chemistry, Journal of Clinical Investigation, eLife, Cell reports, GeroScience etc. During his PhD and postdoctoral training Somasish have attended many international conferences, and have received many honours and awards.  
Very recently Somasish have joined MAHE as an Assistant Professor and Ramalingaswamy Fellow. In this new role, his focus continues in ageing and age related neurodegenerative disorders and tropical infectious diseases such as Melioidosis. He is an active collaborator with Prof. Chiranjay Mukhopadhyay to decipher the molecular mechanisms behind the aetiology of Burkholderia strains in the Indian Subcontinent. Somasish is a firm believer in collaborative scientific ventures and have collaborators in India, USA and Brazil.


Key Publications

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