Dr Subhash Mehto
Immunologist and Cell Biologist
Institute Institute of Life Sciences
Malaria; leishmania; vaccine and drug development
Host-Pathogens interaction, Autophagy, and Inflammation
Dr. Subhash Mehto is an immunologist and cell biologist. He is a recipient of the National Academy of Science, India (NASI) - Platinum Jubilee Young Scientist Award-2019. His research work focuses on Autophagy, inflammation and host-pathogen Interactions.
Jena KK*, Mehto S *, Nath P*, Chauhan NR, Sahu R, Dhar K, Das SK , Kolapalli SP, Murmu KC , Jain A, Chattopadhyay S, Rusten TE, Prasad P , Chauhan S , Chauhan S (2019). Autoimmunity Gene IRGM Supresses cGAS-STING and RIG-MAVS Signalling to control Interferon Response. (EMBO Reports)
Mehto S*, Jena KK*, Nath P, Chauhan S, Kolapalli1 SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S (2019). The Crohn’s disease genetic risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its autophagy. Mol. Cell, 73, 1-17
Jena K, Kolapalli S#, Mehto S#, Nath P, Das B, Ahad A, Syed G , Raghav S , Senapati S, Chauhan S, Chauhan S. (2018) TRIM16 controls assembly and degradation of protein aggregates by modulating the NRF2-p62 axis and autophagy. EMBO J DOI: 15252/embj.201798358) (# Equal Contribution).
Sharma D, Tiwari BK, Mehto S, Antony C, Kak G, Singh Y, et al. (2016) Suppression of Protective Responses upon Activation of L-Type Voltage Gated Calcium Channel in Macrophages during Mycobacterium bovis BCG Infection. PLoS ONE 11(10): e0163845. doi:10.1371/journal.pone.0163845.
Mehto S*, Antony C, Khan N, Arya R, Selvakumar A, Tiwari BK, Vashishta M, Singh Y, Jameel S, Natarajan K (2015) Mycobacterium tuberculosis and Human Immunodeficiency Virus Type 1 Cooperatively Modulate Macrophage Apoptosis via Toll Like Receptor 2 and Calcium Homeostasis. PLoS ONE 10(7): e0131767. doi:10.1371/journal.pone.0131767.