Suraj Parihar

My research interest is to understand the basic infection biology of host-pathogen interactions, to exploit the gene targets as an alternative or adjunctive host-directed therapies. Our research is focused on the mechanisms of macrophage-killing functions and immune responses in Listeriosis and Tuberculosis as well as in Diabetes/TB comorbidity. Using a loss-of-function approach, we are engaged in the identification of novel host factors exploited by intracellular pathogens to evade innate immunity and survive in whole animal models. Subsequently, we assess the translational potential of identified host factors and their associations in disease outcome using patient clinical material. We use transcriptomics, proteomics, metabolomics, repurposed drugs/inhibitors, gene-deficient animal models.