Susanna Dunachie

Susanna Dunachie

Professor

University of Oxford, UK

Tel: +44 (0)7803 042976

Email: Susie.dunachie@ndm.ox.ac.uk

 

 

 

VALIDATE Role:

Network Investigator

 

Research Keywords: 

Melioidosis, human clinical trials, diabetes

 

Biography:

I gained a PhD in malaria vaccines development at Jenner, Oxford and then after completing clinical specialist training in infectious diseases I moved to the Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand in 2011 to establish my research group evaluating immune responses to Burkholderia pseudomallei and Orientia tsutsugamushi (scrub typhus) in human patient populations. Since 2015 I have also run the Tropical Immunology Group at Medawar, Oxford which is working on immune correlates of protection from death in acute melioidosis, and characterising the mechanisms of susceptibility of people with type 2 diabetes to intracellular pathogens. Techniques include ELIspot, flow cytometry, whole blood stimulation field assays, cellular bioenergetics analysis, metabolomics, transcriptomics, flow cytometry and functional growth inhibition assays.I have overseen establishing capacity in Dhaka, Bangladesh for enhanced laboratory microbiological diagnosis and immunology studies.

 

Related Websites: 

Profile page at University of Oxford

 

Key Publications:

T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients. Jenjaroen K, Chumseng S, Sumonwiriya M, Ariyaprasert P, Chantratita N, Sunyakumthorn P, Hongsuwan M, Wuthiekanun V, Fletcher HA, Teparrukkul P, Limmathurotsakul D, Day NP, Dunachie SJ. PLoS Neglected Tropical Diseases. 9(10):e0004152. (2015). PMC4619742

Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen Elispot assay in rhesus macaques and humans. Sumonwiriya M, Sunyakumthorn P, Anantatat T, Jenjaroen K, Chumseng S, Somponpun S, Im-erbsin R, Tanganuchitcharnchai A, Blacksell S,  Teparrukkul P, Limmathurotsakul D, Lombardini E, Burke R, Richards A, Day NP, Paris DH,  Dunachie SJ. In press Plos Neglected Tropical Diseases

A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis. Chaichana P, Chantratita N, Brod F, Jenjaroen K, Chumseng S, Sumonwiriya M, Teparrukkul P, Limmathurotsakul D,. Day NPJ, West TE* and Dunachie SJ*. Plos Neglected Tropical Diseases 2017; 11(5): e0005587 (* joint last author).

Comparison of O-polysaccharide and hemolysin co-regulated protein as target antigens for serodiagnosis of melioidosis. Pumpuang A, Dunachie SJ, Phokrai P, Jenjaroen K, Sintiprungrat K, Boonsilp S, Brett PJ, Burtnick MN, Chantratita N. Plos Neglected Tropical Diseases 2017; 11(3): e0005499

Global Warming: Pandemics, Pathogenicity and Changing Molecular Epidemiology of Cholera. Chowdhury F, Nur Z, Hassan N, von Seidlein L, Dunachie S. Annals of Clinical Microbiology and Antimicrobials. 2017 16:10

Consensus on the Development of Vaccines against Naturally Acquired Melioidosis. Limmathurotsakul D, Funnell SG, Torres AG, Morici LA, Brett PJ, Dunachie S, Atkins T, Altmann DM, Bancroft G, Peacock SJ, Steering Group on Melioidosis Vaccine D. Emerging infectious diseases. 21(6). (2015).

T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis. Reynolds C, Goudet A, Jenjaroen K, Sumonwiriya M, Rinchai D, Musson J, Overbeek S, Makinde J, Quigley K, Manji J, Spink N, Yos P, Wuthiekanun V, Bancroft G, Robinson J, Lertmemongkolchai G, Dunachie S, Maillere B, Holden M, Altmann D, Boyton R. J Immunol. 194(10):4814-24. (2015).

Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model. Dunachie S, Berthoud T, Hill AV, Fletcher HA. Vaccine. 33(40):5321-31. (2015).

A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.       Dunachie, S. J., Walther, M., Epstein, J. E., Keating, S., Berthoud, T., Andrews, L., Andersen, R. F., Bejon, P., Goonetilleke, N., Poulton, I., Webster, D. P., Butcher, G., Watkins, K., Sinden, R. E., Levine, G. L., Richie, T. L., Schneider, J., Kaslow, D., Gilbert, S. C., Carucci, D. J. & Hill, A. V. Infect Immun 74, 5933-42 (2006).

Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. McConkey, S. J., Reece, W. H., Moorthy, V. S., Webster, D., Dunachie, S., Butcher, G., Vuola, J. M., Blanchard, T. J., Gothard, P., Watkins, K., Hannan, C. M., Everaere, S., Brown, K., Kester, K. E., Cummings, J., Williams, J., Heppner, D. G., Pathan, A., Flanagan, K., Arulanantham, N., Roberts, M. T., Roy, M., Smith, G. L., Schneider, J., Peto, T., Sinden, R. E., Gilbert, S. C. & Hill, A. V. Nat Med 9, 729-35 (2003).