Endalew Yizengaw

Endalew Yizengaw

Assistant Professor

Bahir Dar University, Ethiopia

Tel: +251-920249001

Email: endalew02@gmail.com

 

 

 

VALIDATE Role:

Network Associate

 

Research Keywords:

Cutaneous Leishmaniasis

 

Biography:

I am working on leishmaniasis with special emphasis on cutaneous leishmaniasis, which is a neglected tropical disease endemic in my country. Since 2015, I have been part of research projects analysing the immune response in patients suffering from both cutaneous and visceral leishmaniases.

I started my scientific career at the University of Gondar, where I did my MSc. For my project, I analysed neutrophils isolated from patients with visceral leishmaniasis. Next, as part of an MRC research grant, I performed my PhD on identifying different parasite and host factors responsible for the different clinical presentations of cutaneous leishmaniasis (CL).

I am interested in better understanding the disease pathology by recruiting CL patients with early lesions. To understand the role of the host immune response in the pathogenesis of CL and parasite control is yet unanswered area. I also have a plan to know the causative parasites and responsible vectors of CL in Ethiopia. Developing non-invasive and easy to perform diagnostic approaches for CL is also an area of research in Ethiopia. There is also a high use of traditional medicine for the treatment of CL in Ethiopia. I am interested in working on the effectiveness, dose, and mechanisms of the selected medicinal plants for CL. The drug resistance for the current drug, Sodium stibogluconate (SSG), needs to be addressed. These all will help to develop a protective vaccine and/or drug.

 

Related Websites:

Twitter

 

Key Publications:

  • Adem E., Yizengaw E., Mulaw T., Nibret E., Müller I., Takele Y., and Kropf P. Altered co-stimulatory and inhibitory receptors on monocyte subsets in patients with visceral leishmaniasis. Under review in PLoS Negl Trop Dis
  • Yizengaw E, Gashaw B, Yimer M, Takele Y, Nibret E, Yismaw G, Cervera E.C, Ejigu K, Tamiru D, Munshea A, Muller I, Weller R, Cotton J, Chapman L, Kropf P. Demographic characteristics and clinical features of patients presenting with different forms of cutaneous leishmaniasis, in Lay Gayint, Northern Ethiopia. Under review in PLoS Negl Trop Dis
  • Yimer Y†, Takele Y†, Yizengaw E†, Nibret R, Sumova P, Volf P, G Yismaw G, Alehegn M, Rowan A, Müller I, Cotton JA, Chapman LAC, Kropf P. Demographic characteristics and prevalence of asymptomatic Leishmania donovani infection in migrant workers working in an endemic area in Northwest Ethiopia. Frontiers in Epidemiology. †= equal first authorship.
  • Yizengaw E, Nibret E, Yismaw G, Gashaw B, Tamiru D, Munshea A, Takele Y, Müller I, Chapman L, Weller R, Cotton JA, Kropf P. Cutaneous leishmaniasis in a newly established treatment centre in the Lay Gayint district, Northwest Ethiopia. Skin Health Dis. 2023 Mar 17;3(4):e229. doi: 10.1002/ski2.229.
  • Yizengaw E, Semegn EN, Wubetu GY, Abitew AM, Andualem BG, Alemneh MG (2022) Prevalence of Leishmania RNA virus in Leishmania parasites in patients with tegumentary leishmaniasis: A systematic review and meta- analysis. PLoS Negl Trop Dis 16(6): e0010427. https://doi.org/10.1371/journal.pntd.0010427
  • Yizengaw E, Nibret E, Munshea A, Gashaw B. Burden and risk factors of cutaneous 
  • leishmaniasis in Ethiopia: a systematic review and meta-analysis. Int J Dermatol. 2022 Nov;61(11):1336-1345. doi: 10.1111/ijd.16265.
  • Yizengaw E, Getahun M, Tajebe F, Cruz Cervera E, Adem E, Mesfin G, Hailu A, Van der Auwera G, Yardley V, Lemma M, Skhedy Z, Diro E, Yeshanew A, Melkamu R, Mengesha B, Modolell M, Munder M, Müller I, Takele Y, Kropf P. Visceral Leishmaniasis Patients Display Altered Composition and Maturity of Neutrophils as well as Impaired Neutrophil Effector Functions. Front Immunol. 2016 Nov 29;7:517. doi: 10.3389/fimmu.2016.00517. eCollection 2016.