Suzie Madaki Poster 2024

Suzie Madaki

Dr Suzie Madaki

Bayero University, Nigeria

Influence of Single Nucleotide Polymorphism of INF-γ (rs.2430561, +874 A/T) on the Risk of Tuberculosis and Susceptibility to Treatment in Kaduna State, Nigeria


Poster Abstract


Tuberculosis (TB) remains a global health challenge especially in Sub-Saharan Africa, necessitating comprehensive research to understand genetic factors influencing susceptibility and drug resistance. This study investigated the role of single-nucleotide polymorphisms (SNPs) of IFN-γ (rs.2430561, +874 A/T) on the risk of tuberculosis and influence on drug susceptibility among TB patients and assessed the association of this SNP with age and gender among TB patients in Kaduna State.


A total of 140 participants, comprising drug-resistant TB (DR-TB), drug-susceptible TB (DS-TB) patients, and Apparently Healthy Controls (AHCs), were enrolled. Genomic DNA was extracted, and the SNPs was genotyped using PCR-based techniques. Associations between genotypes, alleles, age, and gender were analyzed. Odd ratios and Hardy-Weinberg equilibrium were employed for demographic and genetic analyses.


In DR-TB, significant associations were observed between IFN-γ SNP genotypes/alleles and increased susceptibility, with homozygous (TT) genotype and thymine (T) allele showing higher frequencies. In DS-TB, similar trends were observed, highlighting potential genetic influences on susceptibility. Hardy-Weinberg equilibrium analysis revealed significant deviations in some groups, suggesting genetic variations.


The prevalence of specific genotypes and alleles indicate potential genetic markers for risk assessment. Deviations from Hardy-Weinberg equilibrium suggest population-specific genetic variations. These findings underscore the importance of genetic factors in TB outcomes and advocate for tailored interventions for different populations.

Keywords: Single Nucleotide Polymorphism, IFN-γ, tuberculosis, drug susceptibility and drug resistance, Kaduna State-Nigeria