Erin McMaster Poster 2025
Mrs Erin McMaster
University of Oxford, UK
Investigating the effect of changing environmental conditions on the growth, virulence and genomic sequence of non-tuberculous mycobacteria
Poster Abstract
Non-tuberculous mycobacteria (NTM) are opportunistic pathogens increasingly implicated in human disease, particularly in immunocompromised individuals. Their environmental reservoirs, especially water sources, play a crucial role in their persistence and potential transmission. Understanding the factors influencing NTM growth is essential for assessing their pathogenic potential and for developing interventions that reduce their environmental burden.
In this study, we are investigating the growth, virulence and genomic sequences of Mycobacterium avium, Mycobacterium abscessus, Mycobacterium fortuitum and other NTM strains under varying environmental conditions. We are currently conducting temperature and metal-exposure experiments, as well as UV-exposure experiments, to assess bacterial growth kinetics and environmental adaptability. Additionally, we will examine the role of different water compositions in sustaining NTM growth.
Our preliminary findings provide insights into the environmental persistence of NTM and highlight the potential risks of waterborne mycobacteria in a changing environment associated with global warming and other forms of climate change. This research contributes to a One Health understanding of NTM-related disease and offers valuable insights for developing broader public health strategies aimed at controlling mycobacterial pathogens in the environment.
Biography
Erin McMaster is a molecular biologist with a keen interest in understanding how mycobacteria adapt to their environments and impact health. Her research journey began in Cape Town, South Africa, where she worked on anti-tuberculous drug development, deepening her fascination with these resilient bacteria. Now, as part of Dr Rachel Tanner’s group, she studies how environmental factors shape the survival and immunogenicity of non-tuberculous mycobacteria.
The Tanner Lab takes a One Health approach to TB prevention, investigating how mycobacteria influence immune responses across humans, cattle, and badgers. By integrating environmental microbiology with immunology, Erin aims to contribute to a deeper understanding of mycobacterial infections and potential intervention strategies.
